28.3k views
3 votes
A group of surgeons are trying to decide which type of mesh to use for incisional hernia repair. Their assimilated evidence includes two case series and one randomised controlled trial. What level of evidence is this?

a. III
b. I
c. IV
d. II
e. V

User TimSparrow
by
7.9k points

1 Answer

4 votes

Final answer:

The level of evidence provided by two case series and one randomised controlled trial is limited by the lower level of the case studies. However, because a randomised controlled trial is a higher and more reliable form of evidence, if we have to assign a single level, it would be considered level II.

Step-by-step explanation:

When evaluating the level of evidence provided by medical research, various types of studies are categorized based on their methodological strength and potential for bias. The hierarchy of evidence typically ranks randomised controlled trials (RCTs) as higher level evidence due to their design, which reduces bias and allows for better comparability between treatment groups.

Case series are observational and descriptive studies that lack the controlled aspect of clinical trials and thus are considered to provide a lower level of evidence. According to most systems of classifying levels of evidence, including the Oxford Centre for Evidence-based Medicine, RCTs are categorized as level II evidence, assuming they are of high quality, have sufficient size, and are applicable to the population of interest. On the other hand, case series are generally considered level IV evidence because they involve uncontrolled observations of groups of patients.

Therefore, since the surgeons' evidence is comprised of two case series (level IV) and one RCT (level II), the overall level of evidence is limited by the lower level of the case studies. If we are to assign a single level, it would be level II since the RCT represents a higher and more reliable form of evidence than the case series.

User Tomvodi
by
8.0k points