Final answer:
Tangier's disease leads to cholesterol esters accumulating in cells, due to a deficiency in HDL which normally transports cholesterol for excretion.
Step-by-step explanation:
Tangier's disease is characterized by the accumulation of cholesterol esters within cells. This rare inherited disorder leads to a deficiency in high-density lipoprotein (HDL), often referred to as "good cholesterol." HDL is responsible for transporting cholesterol from cells to the liver for excretion or to be processed into other essential substances. The lack of functional HDL in Tangier's disease results in the abnormal accumulation of cholesterol esters, which can lead to complications such as an enlarged liver or spleen, and increased risk of cardiovascular disease.