Final answer:
Peri-operative administration of antibiotics is the single most important modality for reducing the risks of postoperative wound infection in a 28-year-old man undergoing an appendicectomy for perforated appendicitis.
Step-by-step explanation:
The single most important modality for reducing the risks of post operative wound infection in a 28 year old man undergoing an appendicectomy for perforated appendicitis is peri-operative administration of antibiotics.
Prophylactic antibiotics, when administered before surgery, can significantly reduce the risk of hospital-acquired wound infections. Studies have shown that taking pre-surgery antibiotics can cut the risk of infection by almost half.
By reducing the risk of infection, peri-operative administration of antibiotics can lead to better outcomes for patients, preventing complications, longer illness, and additional surgeries.