Final answer:
Hyperlipidemia, particularly characterized by high levels of LDL, is the strongest predictor of coronary heart disease due to its association with the development of atherosclerosis.
Step-by-step explanation:
Hyperlipidemia, also known as hyperlipoproteinemia or dyslipidemia, is a condition characterized by elevated levels of lipids and lipoproteins in the blood. Studies show that hyperlipidemia is the strongest predictor of coronary heart disease (CHD). This is primarily due to the fact that high levels of low-density lipoproteins (LDL) and low levels of high-density lipoproteins (HDL) contribute to the buildup of plaque in arteries, leading to a condition known as atherosclerosis. Similarly, individuals with the ApoE E2/E2 genotype are more likely to suffer from hyperlipoproteinemia type III, which has a prevalence of 0.02% in the population and also increases the risk of CHD.