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Abetalipoproteinemia causes a severe accumulation of triglycerides in which of the following organ tissues?

A) Liver cells only
B) Liver and intestinal mucosa cells
C) Adipose cells only
D) Liver and heart cells

User Tremmors
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1 Answer

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Final answer:

Abetalipoproteinemia leads to the accumulation of triglycerides in liver and intestinal mucosa cells due to the affected formation and secretion of VLDL and chylomicrons.

Step-by-step explanation:

Abetalipoproteinemia, which is a condition that affects the absorption and metabolism of dietary fats, cholesterol, and fat-soluble vitamins, causes a severe accumulation of triglycerides in liver and intestinal mucosa cells. The disease interferes with the normal formation and secretion of very low-density lipoproteins (VLDL) and chylomicrons, both of which are responsible for the transport of triglycerides from the liver and intestines to other parts of the body. Affected individuals, therefore, experience a buildup of triglycerides in both the liver cells (hepatocytes) and the cells lining the intestinal mucosa (enterocytes).

User Grant Smith
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