Final answer:
Endogenous cannabinoids are naturally occurring substances that interact with receptors in the body to affect various physiological processes, including the modulation of cutaneous itch. Topical corticosteroids like hydrocortisone can reduce inflammation and pruritus by lowering histamine production. Cannabinoids, including THC and CBD, have approved medical uses and are subject to ongoing research.
Step-by-step explanation:
Endogenous cannabinoids are chemicals naturally produced in the body that interact with cannabinoid receptors in various cell membranes, affecting numerous physiological processes. About cutaneous itch, or pruritus, endogenous cannabinoids can modulate the sensation and intensity of itch.
Chemical mediators in the body, such as histamine, play a significant role in inflammatory responses and the sensation of itch. The prescribed topical corticosteroid cream containing hydrocortisone reduces inflammation and pruritus by diminishing the local production of histamine in the skin, thus alleviating symptoms rather than treating the underlying cause of the rash. Cannabinoids have been studied for their potential medical applications, and FDA-approved medications containing THC and CBD are used to treat conditions like nausea from chemotherapy and severe childhood epilepsy. Research is ongoing to explore the benefits of cannabinoids in treating other conditions.