Final answer:
IL-2 is a cytokine involved in the immune response, aiding in T-cell proliferation and immune regulation. It plays an indirect role in allergic reactions which may involve pruritus, where IgE-primed mast cells release mediators like histamine to cause such symptoms. Treatments often include hydrocortisone to suppress these inflammatory responses.
Step-by-step explanation:
IL-2, or Interleukin-2, is a type of cytokine, which is a chemical messenger that plays a crucial role in the body's immune response. IL-2 is primarily produced by T-cells following their activation and is fundamental for T-cell proliferation, a key aspect of the adaptive immune response. IL-2's function is not limited to growth and expansion of T-cells, it also increases the activity of natural killer cells and promotes the differentiation of regulatory T-cells, which help modulate the immune response and prevent autoimmune reactions.
When considering allergic reactions and pruritus (itching), IL-2 can be involved indirectly. Allergic reactions often involve IgE-primed mast cells which release granules and chemical mediators, such as histamine and cytokines, into the afflicted area upon second exposure to an allergen. These chemical mediators are responsible for the allergic and inflammatory responses, including itchiness and rashes.
In the context of treatments like moisturizing creams or topical corticosteroids, ingredients like hydrocortisone are included to alleviate itching and inflammation. Hydrocortisone works by suppressing the production of histamine and other pro-inflammatory cytokines in the skin, thus reducing the immune response and symptoms like pruritus.