Final answer:
IL-31 is produced primarily by activated T-helper cells and plays a role in inflammation and allergic responses. High levels of IL-31 can lead to itching and inflammation in the skin.
Step-by-step explanation:
IL-31 is produced primarily by activated T-helper cells, specifically Th2 cells. It is a cytokine that plays a role in inflammation and allergic responses.
IL-31 is involved in the itching sensation or pruritus that is associated with certain conditions, such as atopic dermatitis and prurigo nodularis.
High levels of IL-31 can lead to the activation of certain signaling pathways in the skin, causing itching and inflammation.