Final answer:
The liver and kidneys are responsible for degrading and excreting hormones from the bloodstream, a process that is regulated by negative feedback loops to maintain homeostasis.
Step-by-step explanation:
The two organs responsible for removing or terminating hormones from the bloodstream to maintain low concentration levels are the liver and the kidneys. These organs play a crucial role in the body's maintenance of homeostasis. For instance, peptide hormones are degraded in the liver and/or kidney, and other hormones like catecholamines, steroids, and thyroid hormones are inactivated by enzymatic modification in the blood and liver.
This degradation and excretion of hormones are essential processes governed by negative feedback loops, which ensure that the concentration of hormones in the blood is maintained within a narrow, optimal range to sustain healthy bodily functions.