Final answer:
Mantle cell lymphomas usually involve a translocation between chromosomes 11 and 14, leading to cyclin D1 overexpression and uncontrolled cell division.
Step-by-step explanation:
Almost all mantle cell lymphomas have a translocation that involves chromosomes 11 and 14. This translocation results in the juxtaposition of the cyclin D1 gene (CCND1) on chromosome 11 with the heavy-chain enhancer region on chromosome 14.
The consequence of this mutation is overexpression of the cyclin D1 protein, which promotes cell cycle progression and leads to uncontrolled cell division, a hallmark of cancer. This translocation is a type of large scale mutation, and such genomic changes can play a pivotal role in the development of certain cancers, such as chronic myelogenous leukemia and, in this case, mantle cell lymphoma.