Final answer:
Psoriasis is the most common autoimmune disease affecting 2-3% of the US population, characterized by abnormal skin patches.
Step-by-step explanation:
The most common autoimmune disease that affects 2-3% of the US population is psoriasis. Psoriasis is considered an organ-specific autoimmune disease that primarily affects the skin, leading to patches of abnormal skin. Other common autoimmune diseases include type I diabetes and multiple sclerosis, both localized to specific body cells, and systemic autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus (SLE), which can affect various organs and tissues.