Final answer:
A chromosome inversion involves a segment of a chromosome breaking, rotating, and reattaching, potentially disrupting gene sequence and leading to recombination issues during meiosis.
Step-by-step explanation:
A chromosome inversion occurs when a segment of a chromosome breaks off, undergoes a 180° rotation, and then reattaches to the same chromosome. This process can result in genetic abnormalities if it disrupts an important gene sequence. Inversions can either be pericentric, involving the centromere, or paracentric, occurring outside of the centromere. During meiosis, these inversions can lead to issues with gene alignment and recombination, potentially causing the production of aneuploid gametes if not properly aligned.