Question

Determining the Beyond Use Date for Non-sterile Compounds:

-Oral formulations containing water
-Topical/Semi-solid formulations (creams, pastes, ointments, gels) containing water Mucosal liquids (mouth coating rinses) containing water
-Non-aqueous formulas

Answer 1

The Beyond Use Date (BUD) for different types of non-sterile compounds varies based on the formulation. Oral formulations containing water have a BUD of no longer than 14 days, while topical and mucosal liquids have a BUD between 30 to 180 days. Non-aqueous formulas have a longer BUD of up to 180 days.

Step-by-step explanation:

The Beyond Use Date (BUD) is the date after which a compounded non-sterile formulation should not be used. The BUD for different types of non-sterile compounds can vary depending on the formulation. Here are some general guidelines for determining the BUD:

1. Oral formulations containing water: The BUD is typically no longer than 14 days, as the presence of water increases the risk of microbial growth.
2. Topical/Semi-solid formulations (creams, pastes, ointments, gels) containing water: The BUD is usually between 30 to 180 days, depending on the specific formulation and ingredients.
3. Mucosal liquids (mouth coating rinses) containing water: The BUD is typically no longer than 14 days, similar to oral formulations.
4. Non-aqueous formulas: The BUD can be longer, up to 180 days, as these formulations have a lower risk of microbial growth.

It's important to note that these are general guidelines, and the BUD should be determined based on the specific formulation, ingredients, and storage conditions. The BUD should be clearly labeled on the compounded product.