Final answer:
To reconstitute a 0.5 g vial of Doxil using the instructions provided, one would theoretically need 104 ml of normal saline, which is calculated by converting the total mass of Doxil to milligrams, dividing by the mass per portion, and multiplying by the volume of saline per portion.
Step-by-step explanation:
The question is asking how much normal saline is needed to reconstitute a vial of Doxil that has a mass of 0.5 grams to the recommended concentration. The instructions specify to reconstitute each 12 mg with 2.5 ml of normal saline. To find the total amount of saline required to reconstitute the entire vial, we need to calculate the number of 12 mg portions in the 0.5 g vial and multiply that by the amount of saline used for each portion.
First, we convert the mass of Doxil in the vial from grams to milligrams:
0.5 grams * 1000 mg/g = 500 mg. Now, we divide the total mass of Doxil by the mass in each portion:
500 mg ÷ 12 mg/portion = approximately 41.67 portions. We then multiply the number of portions by the amount of saline required per portion:
41.67 * 2.5 ml/portion = 104.17 ml. Since medication reconstitution typically requires precise measurements, we would round to the nearest whole number, which gives us 104 ml.
However, none of the provided answer choices match 104 ml exactly. This likely indicates a typo or mistake in the provided answers or the question assumptions.