Question

What would germline DNA analysis show with Li-Fraumeni syndrome?

a) Mutations in the TP53 gene
b) Mutations in the BRCA1 gene
c) Mutations in the APC gene
d) Mutations in the RET proto-oncogene

Answer 1

The correct answer is a) Mutations in the TP53 gene. Li-Fraumeni syndrome is caused by mutations in the TP53 gene, which encodes the p53 protein, a tumor suppressor protein.

Step-by-step explanation:

The correct answer to the question is a) Mutations in the TP53 gene. Li-Fraumeni syndrome (LFS) is a rare hereditary disorder associated with a predisposition to cancer. It is caused by mutations in the TP53 gene, which encodes the p53 protein, a tumor suppressor protein. Mutations in the TP53 gene can result in the loss of p53 function and lead to uncontrolled cell proliferation and an increased risk of cancer.