Final answer:
The main question that the Book of Exodus seeks to answer with regard to God is the relationship between God and humanity.
Step-by-step explanation:
The main question that the Book of Exodus seeks to answer with regard to God is (D) What is the relationship between God and humanity? The book describes the Hebrews' flight from Egypt, their journey through the Sinai desert, and their eventual settlement in Canaan. Throughout this narrative, the relationship between God and humanity is a central theme, as God reveals Himself, issues divine punishments, and gives commandments to be obeyed by the Hebrews. This exploration of the dynamic between God and humanity is one of the main focuses of the Book of Exodus.