Final answer:
Autosomal Dominant Polycystic Kidney Disease can lead to major extra-renal manifestations such as liver cysts and cerebral aneurysms, as well as other complications like mitral valve prolapse and cardiac abnormalities.
Step-by-step explanation:
The major extra-renal manifestations of Autosomal Dominant Polycystic Kidney Disease (ADPKD) include liver cysts and cerebral aneurysms. Liver cysts are a common non-kidney manifestation of ADPKD, which can sometimes lead to hepatic fibrosis or other complications. On the other hand, cerebral aneurysms, particularly in the brain's blood vessels, can be a life-threatening condition due to the risk of bleeding if they rupture. Other possible manifestations include mitral valve prolapse, colonic diverticula, and cardiac abnormalities.