Final answer:
The 'Trail of Tears' is the historical event resulting from the Indian Removal Act, where thousands of Cherokee were forcibly relocated, leading to approximately 4,000 deaths.
Step-by-step explanation:
The tragic historical event which resulted from the Indian Removal Act and led to the deaths of thousands of Cherokee Indians is known as the Trail of Tears. In 1830, the Indian Removal Act was signed by President Andrew Jackson, compelling various Native American tribes to relinquish their lands east of the Mississippi River in exchange for lands to the west.
The removal, which especially affected the Cherokee Nation in 1838, saw the forced displacement of the tribe from Georgia to the designated Indian Territory (present-day Oklahoma). This brutal march led to the death of approximately 4,000 Cherokee due to exposure, disease, and starvation, marking a dark chapter in American history.