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What is indication and MOA of cyclobenzaprine?

User Ponsfrilus
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Final answer:

Cyclobenzaprine is used to treat muscle spasms and acts as a muscle relaxant by reducing tonic motor activity in the central nervous system, particularly in the brain stem. It is not for long-term use and is generally prescribed for short durations under medical supervision.

Step-by-step explanation:

Indications and Mechanism of Action of Cyclobenzaprine

Cyclobenzaprine is primarily indicated for the treatment of muscle spasms associated with acute, painful musculoskeletal conditions. In its role, it acts as a muscle relaxant, aimed to alleviate discomfort and improve mobility.

The mechanism of action (MOA) of cyclobenzaprine involves its central nervous system activity. It is believed to act within the brain stem, particularly at the locus coeruleus, which subsequently reduces tonic somatic motor activity influencing both alpha and gamma motor neurons. This action helps to reduce muscle spasms without directly interfering with muscle function.

Cyclobenzaprine is not intended for long-term use and is typically prescribed for periods of two to three weeks. Its efficacy beyond such durations has not been established. As with any medication, the use of cyclobenzaprine should be under the guidance and prescription of a healthcare professional, considering its potential side effects and contraindications.

User Kaleigh
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