Final answer:
Apomorphine (Apokyn) has precautions, contraindications, and adverse drug reactions (ADRs). Precautions include cardiovascular disease and blood pressure medications. Contraindications include severe hepatic impairment and certain psychiatric disorders. ADRs can include nausea, hypotension, hallucinations, and abnormal movements.
Step-by-step explanation:
Precautions:
- Apomorphine should be used with caution in patients with a history of cardiovascular disease, as it can cause hypotension and syncope.
- Patients who are on medications that lower blood pressure should be closely monitored when using apomorphine.
- Apomorphine should not be used in patients with known hypersensitivity to the drug or its components.
Contraindications:
- Apomorphine is contraindicated in patients with severe hepatic impairment, as it can worsen hepatic function.
- It should not be used in patients with a history of stroke or transient ischemic attack.
- Apomorphine is also contraindicated in patients with certain psychiatric disorders, such as psychosis or severe depression.
Adverse Drug Reactions (ADRs):
- The most common ADRs of apomorphine include nausea, yawning, drowsiness, and dizziness.
- Less common but more serious ADRs include hypotension, syncope, hallucinations, and abnormal involuntary movements.