Final answer:
Omeprazole and lansoprazole are proton pump inhibitors used to reduce gastric acid secretion, treating GERD, peptic ulcers, and Zollinger-Ellison syndrome. Notable contra-indications include hypersensitivity, and adverse effects range from headaches to potential kidney issues.
Step-by-step explanation:
What is Omeprazole and Lansoprazole?
Omeprazole and lansoprazole belong to a class of medications known as proton pump inhibitors (PPIs). Their mechanism of action (MOA) involves inhibiting the hydrogen-potassium adenosine triphosphatase enzyme system of the gastric parietal cells, commonly known as the gastric proton pump. This action significantly reduces gastric acid secretion.
Indications
These medications are indicated for the treatment of conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome, where there is an overproduction of stomach acid.
Contra-indications and Adverse Effects
Major contra-indications include known hypersensitivity to the drug or its components. Adverse effects can include headaches, nausea, abdominal pain, constipation, flatulence, and in rare cases, more serious conditions like kidney issues or osteoporosis with long-term use.