Final answer:
Lubiprostone is a drug used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation. It activates chloride channels in the gastrointestinal tract to increase fluid secretion and motility. Common side effects include nausea, diarrhea, abdominal pain, and headache.
Step-by-step explanation:
Lubiprostone is a medication used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation. It belongs to the class of drugs known as chloride channel activators.
The mechanism of action of lubiprostone involves the activation of type 2 chloride channels in the gastrointestinal tract, which increases intestinal fluid secretion and motility, thereby facilitating the passage of stool.
Some indications for the use of lubiprostone include chronic idiopathic constipation where other treatments have failed, and irritable bowel syndrome with constipation in women aged 18 years and older.
Major contraindications for lubiprostone include known or suspected mechanical gastrointestinal obstruction, history of severe diarrhea or GI obstruction, and hypersensitivity to the drug.
As for adverse effects, common side effects reported with lubiprostone include nausea, diarrhea, abdominal pain, flatulence, and headache. Severe diarrhea may occur in some cases, and patients should be advised to discontinue the medication and seek medical attention if this occurs.