Final answer:
Tricyclic antidepressants like Amitriptyline and Imipramine are commonly used to treat major depression by preventing the reuptake of neurotransmitters in the brain.
Step-by-step explanation:
Tricyclic antidepressants, such as Amitriptyline and Imipramine, are commonly used to treat major depression. These drugs are referred to as tricyclic antidepressants due to their chemical structure. They work by preventing the reuptake of certain neurotransmitters, such as serotonin and norepinephrine, in the brain, leading to an elevated mood in depressed patients over time.