Question

Which second-generation antipsychotic is a partial agonist at D2 and 5-HT1A receptors, as well as an antagonist of 5-HT2A receptors

Answer 1

Aripiprazole (Abilify) is a second-generation antipsychotic that acts as a partial agonist at D2 and 5-HT1A receptors, while also antagonizing 5-HT2A receptors.

Step-by-step explanation:

The second-generation antipsychotic that is a partial agonist at D2 and 5-HT1A receptors, as well as an antagonist of 5-HT2A receptors, is aripiprazole (brand name Abilify).

Aripiprazole acts as a partial agonist at D2 receptors, meaning it can activate these receptors to a certain extent while also blocking the actions of dopamine. It also acts as a partial agonist at 5-HT1A receptors, which are serotonin receptors involved in mood regulation. Lastly, aripiprazole antagonizes 5-HT2A receptors, which are serotonin receptors involved in various functions including cognition and hallucinations.