Final answer:
Risperidone (Risperdal) and olanzapine (Zyprexa) are two atypical antipsychotics that block 5-HT2A receptors to a greater extent than D2 receptors, and are used in the treatment of schizophrenia and bipolar disorder.
Step-by-step explanation:
The two medications that are known to block 5-HT2A receptors to a greater extent than it does D2 receptors are atypical antipsychotics, specifically risperidone (Risperdal) and olanzapine (Zyprexa). These medications are utilized primarily in the treatment of schizophrenia and bipolar disorder.
Risperidone antagonizes D2 and serotonin type 2 receptors, alongside other receptors such as alpha-adrenergic and histaminergic H1 receptors. Olanzapine also has a higher affinity for 5-HT2A receptors compared to D2 receptors.
These atypical antipsychotics differ from typical antipsychotics, which primarily block D2 receptors. By targeting 5-HT2A receptors, atypical antipsychotics can mitigate some of the side effects associated with D2 antagonism, such as extrapyramidal symptoms, and also address symptoms of psychosis that involve serotonin dysregulation.