Final answer:
The nurse should immediately report joint pain experienced by a tuberculosis patient taking pyrazinamide, as it may indicate serious side effects requiring healthcare provider intervention.
Step-by-step explanation:
The nurse should immediately report joint pain to the healthcare provider when it is experienced by a client with tuberculosis taking pyrazinamide. This symptom can indicate a serious side effect of the medication.
Although fatigue, nausea, and decreased appetite are also side effects that can be concerning, joint pain is particularly significant because it can be a sign of drug-induced hepatotoxicity or hyperuricemia, which can lead to gout.
As with most tuberculosis treatments, monitoring for side effects is critical because of the potential impact on liver function and overall health.