Final answer:
Mutations affecting a single gene can lead to dramatic changes in traits, such as the loss of limbs.
Step-by-step explanation:
Dramatic changes in traits, such as the loss of limbs, can occur through the mutations affecting a single gene.
Mutations can cause changes in an organism's DNA sequence, which can lead to altered traits and phenotypes. For example, if a mutation occurs in a gene responsible for limb development, it could result in the loss of limbs in an organism.
Therefore, the statement is True.