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Ethosuximide initial dosing in children 3-6

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Final answer:

Ethosuximide dosing in children aged 3-6 starts at 10-20 mg/kg/day, divided into once or twice-daily dosing. It is incrementally adjusted, with careful monitoring, to achieve seizure control. Dosing should be tailored by a physician to the child's needs and monitored for side effects.

Step-by-step explanation:

The initiation of ethosuximide dosing in children aged 3-6 typically starts at a lower dose which may be slowly increased based on the patient's response and tolerability. It's essential to follow a physician's guidance because dosing is nuanced and needs to be adjusted according to the child's weight, seizure frequency, and potential side effects.

The starting dose is often around 10-20 mg/kg/day, given in one or two divided doses. Over time and with careful monitoring, the dose may be increased until seizure control is achieved, usually not exceeding 40 mg/kg/day. It should be noted that dosing recommendations can vary and it's critical to tailor the administration of the drug to the individual needs of the child.

It's also important to monitor for side effects when starting or adjusting the dose of ethosuximide, as children are particularly sensitive to medication changes. Side effects can include drowsiness, dizziness, nausea, and more serious effects such as blood disorders or liver toxicity, though these are rare.

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