Final answer:
Polycystic ovarian syndrome (PCOS) is associated with the major endocrine abnormality of hyperinsulinemia. PCOS is a hormonal disorder that affects the ovaries and can lead to irregular menstrual periods, weight gain, acne, and excess facial hair.
Step-by-step explanation:
Polycystic ovarian syndrome (PCOS) is associated with the major endocrine abnormality of hyperinsulinemia. PCOS is a hormonal disorder that affects the ovaries and can lead to irregular menstrual periods, weight gain, acne, and excess facial hair. The underlying cause of PCOS is not definitively known, but it is thought that insulin resistance plays a role. Insulin resistance can lead to high blood glucose levels and an increase in androgen production, contributing to the development of PCOS.