Final answer:
The protocol for verifying e-mail addresses against IP addresses to reduce spam is called Sender Policy Framework (SPF).
Step-by-step explanation:
The protocol that verifies e-mail addresses against IP addresses to reduce spam is called Sender Policy Framework (SPF). SPF allows the receiving mail server to check the validity of the sender's IP address and domain against the DNS records of the sender's domain. This helps to prevent email spoofing and spam by ensuring that only legitimate email servers can send emails on behalf of a specific domain.