Final answer:
The suffix '-gen' in collagen indicates the generation or producing nature of the substance. Collagen is crucial for tissue integrity, and mutations or deficiencies can lead to diseases like Ehlers-Danlos syndrome and osteogenesis imperfecta, which affect connective tissues and bones.
Step-by-step explanation:
The suffix '-gen' in the term collagen suggests the compound or element is generating or producing something. In the context of collagen, '-gen' refers to producing the substance that is part of the extracellular matrix (ECM) and plays a vital role in the structure and integrity of various tissues, such as skin, bone, and connective tissue.
Regarding collagen diseases like Ehlers-Danlos syndrome, the deficiency or mutation in collagen affects the strength and function of the connective tissue, leading to symptoms such as skin and vascular issues. Osteogenesis imperfecta is another condition related to collagen defects. Patients with this genetic disorder frequently experience problems with bone development and repair due to improper production and processing of collagen, leading to symptoms like increased bone fragility and frequent fractures.