Final answer:
Probenecid, along with adequate hydration, is given with cidofovir to decrease the risk of nephrotoxicity by reducing the drug's concentration in the kidneys.
Step-by-step explanation:
The medication that can be given with cidofovir to decrease the risk of nephrotoxicity is probenecid. Nephrotoxicity is a potentially harmful side effect of cidofovir, which is a drug used to treat viral infections such as cytomegalovirus (CMV) in patients with AIDS. Probenecid works by reducing the renal tubular secretion of cidofovir, thus decreasing its concentration in the kidneys and lowering the risk of kidney damage.
In addition to probenecid, adequate hydration with intravenous saline is also recommended before and after administration of cidofovir to further minimize nephrotoxic risk. This protocol is important in the management of patients receiving cidofovir to ensure their safety while effectively treating their viral infection.