Question

Which of the following is a contraindication for the administration of tissue plasminogen activator (t-PA)?

a. Intracranial hemorrhage
b. Ischemic stroke
c. Age 18 years of age or older
d. Systolic blood pressure less than or equal to 185 mm Hg

Answer 1

Intracranial hemorrhage is a contraindication for the administration of tissue plasminogen activator (t-PA), a thrombolytic agent used in the treatment of thrombotic strokes.

Step-by-step explanation:

One of the contraindications for the administration of tissue plasminogen activator (t-PA), a thrombolytic agent used to treat thrombotic strokes, is the presence of an intracranial hemorrhage. While t-PA can significantly improve the prognosis of patients who have suffered a thrombotic stroke when administered within 3 hours of the stroke onset, its use is not safe if the stroke is hemorrhagic in nature, as t-PA can exacerbate bleeding. The correct choice in this case is option (a) Intracranial hemorrhage.