Final answer:
The prophylactic dose of Maxeran for CINV typically ranges from 10 to 20 mg in adults, taken 30 minutes before chemotherapy and repeated as needed. Dosing should be guided by dosing guidelines provided by health professionals, considering individual patient factors and chemotherapy protocols.
Step-by-step explanation:
The question pertains to the prophylactic dose of a medication known as Maxeran (which is a trade name for metoclopramide) for preventing chemotherapy-induced nausea and vomiting (CINV). However, the details provided seem to relate to the pharmacokinetics of a different drug (medication): Zofran (ondansetron), which is also used to prevent CINV. It is important to clarify that the dosing of Maxeran (metoclopramide) for CINV prophylaxis in humans typically involves oral or intravenous administration, with adult doses often ranging from 10 to 20 mg taken 30 minutes before chemotherapy, and then every 2 to 6 hours as needed, but these can vary based on individual patient factors and specific chemotherapy regimens. The dose for mice provided in the question (1 mg kg⁻¹ IV or 10 mg kg⁻¹ orally) does not directly translate to human doses without careful conversion and consideration of interspecies differences. As for the reference to Cmax, AUC, and F, these are pharmacokinetic parameters: maximum concentration, area under the curve, and bioavailability, respectively, that are used to quantify drug exposure and effectiveness but are typically not directly used to determine patient dosing. When dealing with medications like Maxeran and Zofran, it is crucial to follow dosing guidelines provided by health authorities or pharmaceutical manufacturers.