Final answer:
The nurse should anticipate the administration of large doses of I.V. antibiotics for a client with acute osteomyelitis post an open fracture of the femur, as this form of delivery provides higher drug concentrations directly to the site of infection, which is essential for effective treatment.
Step-by-step explanation:
In planning care for a client with acute osteomyelitis that developed after an open fracture of the right femur, the nurse should anticipate the need for administering large doses of I.V. antibiotics as ordered. This is crucial as osteomyelitis is an inflammation of bone tissue most often caused by an infection, typically requiring aggressive antibiotic therapy, especially when resulting from an open fracture. Since oral antibiotics may not provide sufficient concentrations at the site of infection and for the systemic effects required, intravenous antibiotics are the preferred method of delivery. This allows for higher local drug levels in the infected bone and more effective eradication of the causative organisms. Consequently, instructing the client to ambulate twice daily, withholding all oral intake, or administering large doses of oral antibiotics would generally not be appropriate initial steps in managing acute osteomyelitis.