Final answer:
Mammographic appearance can be normal in 50 to 93 percent of patients with Paget's disease of the breast. Paget's disease often presents with clinical signs rather than mammographic findings, making biopsy and additional diagnostic methods crucial.
Step-by-step explanation:
The mammographic appearance can be normal in 50 to 93 percent of patients with Paget's disease of the breast. Paget's disease is a rare type of cancer that typically affects the skin of the nipple and often the darker circle of skin around it, known as the areola. Women with this disease sometimes have underlying ductal breast carcinoma, which may or may not be detectable through mammography. Hence, a significant percentage of Paget’s disease cases present with a normal mammogram, and additional diagnostic methods such as a clinical breast exam, nipple discharge examination, and skin biopsy are crucial for accurate diagnosis.