Final answer:
The most appropriate initial step in resuscitation for a newborn who is flaccid, cyanotic, and not responsive after a normal vaginal delivery is oropharyngeal suction and mask ventilation with 100% oxygen followed by chest compressions when a second person is available.
Step-by-step explanation:
The most appropriate initial step in resuscitation for a newborn who is flaccid, cyanotic, and not responsive after a normal vaginal delivery is option E: oropharyngeal suction and mask ventilation with 100% oxygen followed by chest compressions when a second person is available.
After birth, the newborn's first breath inflates the lungs and closes the three shunts that directed oxygenated blood away from the lungs and liver during fetal life. Oropharyngeal suction can help clear any mucus obstructing the airway, and mask ventilation with 100% oxygen can aid in initiating breaths. Chest compressions are performed when the newborn does not respond to initial steps.
Other options listed in the question, such as endotracheal intubation, epinephrine administration, and intraosseous administration, are not the most appropriate initial steps in resuscitation for this scenario.