Final answer:
Necrosis can be caused by factors such as physical trauma, infections, toxins, chemicals, and nuclear radiation. The negative effects of necrosis include inflammation, chronic health issues, the need for surgical removal of dead tissue, and potentially fatal conditions such as sepsis.
Step-by-step explanation:
What might cause necrosis? Necrosis is the death of body tissue, which occurs when too little blood flows to the tissue. Many factors can lead to necrosis, including frostbite, significant physical trauma, infections, toxins, exposure to certain chemicals, and nuclear radiation. For example, high doses of radiation can directly damage DNA within cells, leading to cell death. Infectious agents, like bacteria that cause necrotizing fasciitis, can also produce toxins that contribute to tissue death.
What are some negative effects of necrosis? The consequences of necrosis can range from localized tissue damage to systemic effects, depending on the extent and location of the tissue death. This can include inflammation, which is the body's initial response to injury and serves to limit further damage. Chronic inflammation, however, can become harmful and lead to diseased conditions such as arthritis or persistent infections. Necrosis also requires removal of dead tissue by the body, which can sometimes necessitate surgical intervention, and in severe cases, can result in organ failure or sepsis, a life-threatening systemic response to infection.