Final answer:
The adverse effect seen in a female client with gonadotropin deficiency undergoing HRT is thrombosis. HRT can increase risks of serious health issues including thrombosis, stroke, heart attack, and certain cancers.
Step-by-step explanation:
Among the side effects of hormone replacement therapy (HRT), which is used to treat symptoms of menopause, the answer to which adverse effect can be seen in a female client with gonadotropin deficiency undergoing hormone replacement therapy is thrombosis (a). The use of HRT can lead to an increased risk of various health issues including stroke or heart attack, blood clots, and certain types of cancer among other complications. The physiological strain caused by HRT can be significant, and while it offers protection from conditions like osteoporosis and may potentially reduce symptoms of depression, it does come with the risk of potentially severe and fatal side effects.