Final answer:
The varicella-zoster virus mainly affects older individuals because younger individuals have either had chickenpox or received the vaccine, resulting in a robust immune response.
Step-by-step explanation:
The varicella-zoster virus (HHV-3) mainly affects older individuals because younger individuals have either had a recent chickenpox infection or have received the vaccine, which usually results in a robust immune response developed against the virus. Chickenpox, caused by the varicella-zoster virus, is a common childhood disease that typically occurs in younger individuals and confers immunity against future infections. As a result, older individuals who did not have chickenpox as a child or did not receive the vaccine are more susceptible to the virus.