Final answer:
The two most common drugs for GI anaerobic coverage are metronidazole and oral vancomycin. Metronidazole is a first-line treatment, while oral vancomycin is specifically used for Clostridium difficile infections.
Step-by-step explanation:
The two most common drugs used for GI anaerobic coverage are metronidazole and oral vancomycin. Metronidazole is often the first choice for treating anaerobic bacterial infections because of its efficacy and it has a good penetration into GI tissues. It's particularly effective against bacteria like Bacteroides and Clostridium species. Oral vancomycin is specifically indicated for the treatment of Clostridium difficile infections which are a common cause of antibiotic-associated diarrhea. It's essential to use these antibiotics appropriately, as misuse can lead to antibiotic resistance and other health issues.