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*Real World:* Many antidepressants increase levels of NTs in the brain, but the effects take longer to appear than the changes in neurochemistry. What is the reason for this delay?

User Pmandell
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Final answer:

Antidepressants increase levels of neurotransmitters in the brain, but it takes time for their effects to appear. The delay is due to the brain needing time to adjust and for the neurotransmitter levels to reach a stable state.

Step-by-step explanation:

Antidepressants increase levels of neurotransmitters (NTs) in the brain, but it takes longer for their effects to appear than the changes in neurochemistry. The reason for this delay is that it takes time for the brain to adjust and for the neurotransmitter levels to reach a stable and effective state.

Let's use the example of selective serotonin reuptake inhibitors (SSRIs), which are a type of antidepressant. SSRIs work by blocking the reuptake of serotonin, a neurotransmitter that is often reduced in people with depression. By blocking the reuptake, SSRIs increase the amount of serotonin available in the synaptic cleft, enhancing the signaling between neurons.

However, this process of increasing serotonin levels and restoring normal brain function takes time. The brain needs to adapt to the changes and make adjustments to its receptors and signaling pathways. This is why it can take several weeks for the effects of antidepressants to be fully felt.

User Dario Corno
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