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Local anesthetics

A. do not readily pass the blood-brain barrier.
B. interfere with the propagation of action
potentials in nerve fibres.
C. selectively interfere with the propagation of
action potentials in nociceptive fibres.
D. do not have an effect on any other tissue than
the nervous tissue.

User Alobodzk
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1 Answer

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Final answer:

Local anesthetics like lidocaine prevent pain by blocking sodium channels on nerve cells, stopping action potentials, and with that, pain signals. They work on all parts of the nervous system and are reversible, causing only temporary sensory and motor paralysis without permanent damage.

Step-by-step explanation:

Local anesthetics, such as lidocaine and novocaine, function by blocking sodium channels on neuronal membranes. This blockade prevents sodium ions from entering the nerve cell, which is crucial for the initiation and propagation of action potentials - the electrical signals that neurons use to communicate. Without these signals, there is no sensation of pain transmitted to the brain. One key attribute of local anesthetics is their ability to cause reversible sensory and motor paralysis in the targeted area without causing permanent structural damage to the nerve fibers.

Local anesthetics act on any part of the nervous system and on every type of nerve fiber. When applied to the motor cortex, they prevent impulse transmission, leading to paralysis. When injected into the skin, they block sensory nerve impulses, effectively providing analgesia. Their action is specific to the nervous system, although they do not selectively target nociceptive fibers only. They may affect other nerve fibers and can cause both sensory and motor paralysis in the area innervated.

The effectiveness of local anesthetics primarily lies in their reversible nature and their selectivity in blocking pain without affecting consciousness, unlike general anesthetics. It is also noteworthy that these drugs do not readily cross the blood-brain barrier, thus their effects are localized and do not affect central nervous processing.

User Ke Zhang
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