Final answer:
The primary cause of generalized aggressive periodontitis is bacterial plaque, which leads to microbial infection and inflammation in the periodontal tissues.
Step-by-step explanation:
The primary etiologic factor for generalized aggressive periodontitis is D. Bacterial plaque. Periodontal disease, including generalized aggressive periodontitis, is typically caused by the accumulation of bacterial plaque on the teeth. Microbial infection stemming from this plaque is responsible for the inflammation and tissue damage seen in periodontal diseases.
Bacteria such as Porphyromonas, Streptococcus, and Actinomyces colonize the gingival space as the plaque builds up, contributing to the progression from gingivitis to more severe forms like periodontitis. The condition is often treatable with good dental hygiene and professional cleaning, and in severe cases, antibiotics such as tetracycline, doxycycline, or macrolides may be prescribed.