Question

Which of the following drugs are classic antagonists

for curare over-dosage?
A. Anticholinesterases.
B. Ganglionic stimulants.
C. Ganglionic blocking agents.
D. Alpha adrenergic blocking agents.
E. Beta adrenergic blocking agents.

Answer 1

For curare overdose, the antidote is anticholinesterases, as they inhibit the breakdown of acetylcholine, allowing it to outcompete curare at the neuromuscular junction and reverse paralysis.

Step-by-step explanation:

The classic antagonists for curare overdose are anticholinesterases. Curare causes muscle paralysis by blocking the nicotinic acetylcholine receptors at the neuromuscular junction, which prevents acetylcholine from triggering muscle contraction. Anticholinesterases inhibit the enzyme acetylcholinesterase, which normally breaks down acetylcholine. By inhibiting this enzyme, anticholinesterases allow the accumulation of acetylcholine in the synapse, which can then outcompete curare at the receptors and restore neuromuscular function. Therefore, the correct answer to the question is A. Anticholinesterases.

To counteract an overdose of curare, classic antagonists such as anticholinesterases are used. Anticholinesterases work by inhibiting the breakdown of acetylcholine, allowing more acetylcholine to be available at the neuromuscular junction and helping to restore muscle function.