Question

Anti-thrombotic therapy with ___ (2) is recommended for all patients with mechanical aortic or mitral valve replacement to reduce the rates of systemic thromboembolism.

Target INR for aortic valves without risk factors is ___ .

Target INR for mechanical aortic valves with high risk features (e.g. A. fib, LV dysfunction with EF less than 30%, prior thromboembolism, presence of hypercoagulable state) and mechanical mitral valves is ___

Answer 1

Anti-thrombotic therapy with Warfarin is recommended for patients with valve replacements, with a target INR of 2.0 to 3.0 for aortic valves without risk factors, and 2.5 to 3.5 for aortic valves with high-risk features and mechanical mitral valves.

Step-by-step explanation:

Anti-thrombotic therapy with Warfarin (Coumadin) is recommended for all patients with mechanical aortic or mitral valve replacement to reduce the rates of systemic thromboembolism. The target International Normalized Ratio (INR) for aortic valves without risk factors is 2.0 to 3.0. For mechanical aortic valves with high-risk features (e.g., atrial fibrillation, left ventricular dysfunction with ejection fraction less than 30%, prior thromboembolism, presence of hypercoagulable state) and mechanical mitral valves, the target INR is 2.5 to 3.5.