Final answer:
Prolonged NSAID therapy is the most likely cause of osteoporosis, glaucoma, hypertension, and peptic ulcers in a 65-year-old with Crohn's disease.
Step-by-step explanation:
The most likely cause of osteoporosis, glaucoma, hypertension, and peptic ulcers in a 65-year-old with Crohn's disease is prolonged NSAID therapy. While NSAIDs are commonly used to manage inflammation in Crohn's disease, their long-term use can result in significant side effects. Osteoporosis may occur due to the negative impact on bone metabolism, glaucoma can be a consequence of increased intraocular pressure, hypertension may result from alterations in renal function, and peptic ulcers are associated with NSAID-induced gastrointestinal irritation. It underscores the importance of monitoring and managing medication regimens in individuals with chronic conditions to minimize adverse effects on various organ systems.