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Methemoglobinemia is a potential complication of

an excessive dose of
A. bupivacaine.
B. lidocaine.
C. mepivacaine.
D. prilocaine.

1 Answer

2 votes

Final answer:

Methemoglobinemia is a condition caused by high levels of methemoglobin in the blood, impairing the oxygen-carrying capacity of hemoglobin. Prilocaine is the drug among the options given that is known to potentially cause methemoglobinemia when administered in excessive doses. This condition can lead to severe symptoms and requires immediate medical attention.

Step-by-step explanation:

Methemoglobinemia is a potential complication of taking an excessive dose of certain medications. This condition occurs when there is an abnormally high level of methemoglobin in the blood, which affects the oxygen-carrying capacity of hemoglobin since ferric iron (Fe³⁺) cannot bind to oxygen effectively. Methemoglobin is dark brown in color and normally, only 1.7 to 2.4% of total hemoglobin will be in the form of methemoglobin. However, exposure to certain drugs can increase the percentage of methemoglobin, leading to symptoms such as cyanosis and dyspnea. The specific drug among the options that can lead to an excessive increase in methemoglobin levels, causing methemoglobinemia, is prilocaine. Prilocaine has been associated with this condition because of its potential to induce oxidation of hemoglobin more readily than other local anesthetics.

It's important to note that while methemoglobin can be helpful in certain cases, such as counteracting cyanide poisoning by forming cyanomethemoglobin, excessive levels can be harmful. Methemoglobinemia can cause various symptoms including possible cherry-red skin, confusion, nausea, gasping for air, seizures prior to death, and metabolic acidosis.

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