Question

47, XX +18 - Mutation of the 18th pair of chromosomes - Aka Edward's Syndrome - After 1 year 5-25% survival rate - After age 10 , 15 survival - Little know for sure - Possibly heritable , mothers age IS a factor.Explain the genetic mutation of Trisomy 18

Answer 1

Trisomy 18, or Edward's syndrome, is a genetic condition where there is an extra copy of chromosome 18. It is caused by chromosomal nondisjunction during meiosis and disrupts the balance of gene expression. Maternal age is a factor in the occurrence of trisomy 18.

Step-by-step explanation:

Trisomy 18, also known as Edward's syndrome, is a genetic condition where there is an extra copy of chromosome 18, resulting in a total of 47 chromosomes. Trisomy 18 is caused by chromosomal nondisjunction during meiosis, which is when the chromosomes fail to separate properly. This extra chromosome disrupts the balance of gene expression and leads to developmental challenges and physical abnormalities. The survival rate for individuals with trisomy 18 is low, with only 5-25% surviving their first year and around 15% surviving past the age of 10.

Trisomy 18 is not usually inherited and occurs randomly, although it is more common in pregnancies where the mother is older. Maternal age is a factor in the occurrence of trisomy 18, with older women being more likely to have a fetus with this condition. It is important to note that the information available about trisomy 18 is limited and there is still much to learn about this genetic mutation.