Final answer:
The Indian Removal Act of 1830 resulted in the seizure of approximately 15,000,000 acres of land once owned by the Indians.
Step-by-step explanation:
The Indian Removal Act of 1830 resulted in the seizure of a large amount of land once owned by the Indians. One of the most significant instances of forced removal was the infamous "Trail of Tears" between 1831 and 1838, which saw nearly fifty thousand Cherokee, Seminole, Choctaw, Chickasaw, and Creek people relocated to what is now Oklahoma. This act resulted in the seizure of approximately 15,000,000 acres of land from Native tribes.